SV2B

Function

Probably plays a role in the control of regulated secretion in neural and endocrine cells.

(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.

Post-translational modifications

N-glycosylated.

The N-terminal cytoplasmic domain is phosphorylated by CK1.

Sequence Similarities

Belongs to the major facilitator superfamily.

Cellular localization

• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle membrane
• Multi-pass membrane protein
• Cytoplasmic vesicle
• Secretory vesicle
• Acrosome
• Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity).

Alternative names

KIAA0735, SV2B, Synaptic vesicle glycoprotein 2B

Database links

swissprot:Q7L1I2 entrezGene:9899 swissprot:Q6IAR8 omim:185861