Sycp1
Domain
The molecule is in a coiled coil structure that is formed by 4 polypeptide chains. The N-terminal region exhibits a prominent seven-residues periodicity.
Function
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:16717126). Required for normal assembly of the central element of the synaptonemal complexes (PubMed:15937223). Required for normal centromere pairing during meiosis (PubMed:22761579). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:15937223).
Tissue Specificity
Detected in testis (PubMed:15937223). Detected in spermatocytes (at protein level) (PubMed:22761579).
Cellular localization
- Nucleus
- Chromosome
- Chromosome
- Centromere
- In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (PubMed:22761579).
Alternative names
Scp1, Sycp1, Synaptonemal complex protein 1, SCP-1