Sycp3
Domain
Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.
Function
Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:11311943, PubMed:22761579). Required for centromere pairing during meiosis in male germ cells (PubMed:22761579). Required for normal meiosis during spermatogenesis and male fertility (PubMed:10678170). Plays a lesser role in female fertility (PubMed:10678170, PubMed:12004129). Required for efficient phosphorylation of HORMAD1 and HORMAD2 (PubMed:22346761).
Post-translational modifications
Phosphorylated.
Sequence Similarities
Belongs to the XLR/SYCP3 family.
Tissue Specificity
Detected in oocytes (PubMed:16717126). Detected in spermatocytes and testis (at protein level) (PubMed:10678170, PubMed:16717126, PubMed:22761579).
Cellular localization
- Nucleus
- Chromosome
- Chromosome
- Centromere
- It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres (By similarity). The phosphorylated form localizes preferentially to unsynapsed chromosomal regions (PubMed:22346761).
Alternative names
Scp3, Sycp3, Synaptonemal complex protein 3, SCP-3