Syn1 phospho S603
Domain
The A region binds phospholipids with a preference for negatively charged species.
Function
Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:11685225). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (PubMed:11867766).
Post-translational modifications
Substrate of different protein kinases. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover (PubMed:10571231, PubMed:11685225).
Sequence Similarities
Belongs to the synapsin family.
Cellular localization
- Synapse
- Golgi apparatus
- Presynapse
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle
- Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity.
Alternative names
Synapsin-1, Synapsin I, Syn1