Synapsin I

The A region binds phospholipids with a preference for negatively charged species.

Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis (PubMed:7568107). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (By similarity).

Substrate of different protein kinases. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover.

Belongs to the synapsin family.

• Synapse
• Golgi apparatus
• Presynapse
• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle
• Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity.

Syn-1, Syn1, Synapsin-1, Synapsin I

• entrezGene:20964
• swissprot:O88935

Proteins

Neuroscience

74097Da