Synaptobrevin homolog YKT6
Domain
The longin domain regulates palmitoylation and membrane targeting.
Function
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
Post-translational modifications
Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
Farnesylation is required for Golgi targeting.
Sequence Similarities
Belongs to the synaptobrevin family.
Cellular localization
- Cytoplasm
- Cytosol
- Cytoplasmic vesicle membrane
- Lipid-anchor
- Cytoplasmic side
- Golgi apparatus membrane
- Lipid-anchor
- Cytoplasmic side
- Probably cycles through vesicles between Golgi and endosomes.
Alternative names
Synaptobrevin homolog YKT6, YKT6