Synaptotagmin-5
Function
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
Sequence Similarities
Belongs to the synaptotagmin family.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Single-pass membrane protein
- Recycling endosome membrane
- Single-pass membrane protein
- In mast cells, localizes to the endocytic recycling compartment.
Alternative names
Synaptotagmin-5, Synaptotagmin V, SytV, SYT5