Synj1
Domain
Interacts with EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats.
The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2 and SH3GL3.
Function
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Sequence Similarities
Belongs to the synaptojanin family.
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
Cellular localization
- Cytoplasm
- Perinuclear region
Alternative names
Kiaa0910, Synaptojanin-1