Syntaxin-12
Function
SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Sequence Similarities
Belongs to the syntaxin family.
Cellular localization
- Endosome membrane
- Single-pass type IV membrane protein
- Golgi apparatus membrane
- Single-pass type IV membrane protein
- Endomembrane system
- Single-pass type IV membrane protein
- Cytoplasmic side
- Early endosome membrane
- Single-pass type IV membrane protein
- Recycling endosome membrane
- Single-pass type IV membrane protein
Alternative names
Syntaxin-12, STX12