Syntaxin-binding protein 3
Function
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
Post-translational modifications
Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.
Sequence Similarities
Belongs to the STXBP/unc-18/SEC1 family.
Tissue Specificity
Megakaryocytes and platelets.
Cellular localization
- Cytoplasm
- Cytosol
- Cell membrane
- In platelets, predominantly cytosolic. Low amounts membrane-associated.
Alternative names
Syntaxin-binding protein 3, Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, PSP, Unc18-3, Unc-18C, STXBP3