SYP
GeneName
SYP
Summary
SYP, also known as synaptophysin or BM89 antigen, is a 34 kDa integral membrane protein primarily expressed in neurons. It is a key component of synaptic vesicles, localised to the presynaptic membrane and involved in the organisation and maturation of synaptic vesicles. SYP plays a crucial role in synaptic transmission by regulating synaptic vesicle priming and endocytosis, thereby influencing both short-term and long-term neuronal synaptic plasticity. Its presence at excitatory synapses and neuromuscular junctions highlights its importance in neurotransmitter release and neuronal communication.
Importance
SYP is relevant to: - Understanding synaptic mechanisms in neurodegenerative diseases, as alterations in synaptic vesicle dynamics can contribute to neuronal dysfunction. - Research on synaptic plasticity, which is fundamental to learning and memory processes. - Investigating the role of synaptic proteins in psychiatric disorders, where synaptic transmission may be disrupted. - The development of targeted therapies for neurological conditions by providing insights into synaptic vesicle biology and its regulatory pathways.
Top Products
For researchers investigating SYP, we highly recommend the Anti-Synaptophysin antibody [YE269] (ab32127). This top-selling recombinant antibody has garnered an impressive 430 citations, underscoring its reliability and trust within the scientific community. It has been validated in knockout models and is suitable for a variety of applications, including Western blotting (WB), immunohistochemistry (IHC), and immunocytochemistry (ICC). This versatility makes it an excellent choice for those seeking consistent and effective detection of synaptophysin in their studies. The Anti-Synaptophysin antibody [SP11] - Synaptic Marker ELISA Kit (ab16659), supported by 33 citations, is an excellent option for researchers looking to accurately measure synaptophysin levels in their samples.
Abcam Product Citation Summary
The data indicates a significant focus on the use of SYP antibodies in various studies related to synaptic function and plasticity, particularly in mouse and rat models. The applications primarily involve Western blotting and immunohistochemistry, highlighting the importance of SYP in understanding neurological conditions and synaptic changes. Studies also explore the effects of different treatments and conditions, such as stress, Alzheimer's disease, and neuronal differentiation.
Abcam Product Citation Table
Domain
The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Involvement in disease
Intellectual developmental disorder, X-linked 96
XLID96
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.
Sequence Similarities
Belongs to the synaptophysin/synaptobrevin family.
Tissue Specificity
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3 (PubMed:8838578). Expressed in the putamen (at protein level) (PubMed:17296554).
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Multi-pass membrane protein
- Synapse
- Synaptosome
Alternative names
Synaptophysin, Major synaptic vesicle protein p38, SYP