SYP

Domain

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

Involvement in disease

Mental retardation, X-linked 96

MRX96

A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

Sequence similarities

Belongs to the synaptophysin/synaptobrevin family.

Tissue specificity

Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.

Cellular localization

• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle membrane
• Multi-pass membrane protein
• Cell junction
• Synapse
• Synaptosome

Alternative names

• Synaptophysin
• Major synaptic vesicle protein p38
• SYP

Database links

• entrezGene:6855
• omim:313475
• swissprot:P08247

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

33845Da