SYP

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

Intellectual developmental disorder, X-linked 96

XLID96

A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

None

The disease is caused by variants affecting the gene represented in this entry.

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

Phosphorylated by SRC.

Belongs to the synaptophysin/synaptobrevin family.

Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3 (PubMed:8838578). Expressed in the putamen (at protein level) (PubMed:17296554).

• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle membrane
• Multi-pass membrane protein
• Synapse
• Synaptosome

Synaptophysin, Major synaptic vesicle protein p38, SYP

• entrezGene:6855
• omim:313475
• swissprot:P08247

Proteins

Neuroscience

33845Da