Syp
Domain
The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity.
Post-translational modifications
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.
Sequence Similarities
Belongs to the synaptophysin/synaptobrevin family.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Multi-pass membrane protein
- Synapse
- Synaptosome
Alternative names
Synaptophysin, BM89 antigen, Major synaptic vesicle protein p38, Syp