SYT3
Domain
The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
Function
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Sequence Similarities
Belongs to the synaptotagmin family.
Tissue Specificity
Expressed in melanocytes (PubMed:23999003).
Cellular localization
- Cell membrane
- Single-pass membrane protein
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Single-pass membrane protein
Alternative names
Synaptotagmin-3, Synaptotagmin III, SytIII, SYT3