SYT8
Domain
The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.
The second C2 domain/C2B is responsible for SYNCRIP and inositol 1,3,4,5-tetrakisphosphate (IP4)-binding.
Function
Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells.
Sequence Similarities
Belongs to the synaptotagmin family.
Cellular localization
- Cell membrane
- Single-pass type III membrane protein
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
Alternative names
Synaptotagmin-8, Synaptotagmin VIII, SytVIII, SYT8