T-cell differentiation antigen CD6
Function
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Post-translational modifications
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues (By similarity). Phosphorylated on tyrosine residues in response to stimulation of the TCR complex (PubMed:24584089).
Glycosylated.
Tissue Specificity
Expressed predominantly in thymus, lymph node and spleen.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with the TCR/CD3 complex at the immunological synapse.
Alternative names
CD6, T-cell differentiation antigen CD6, Cd6