Tac1
Function
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Post-translational modifications
Substance P
The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Sequence Similarities
Belongs to the tachykinin family.
Cellular localization
- Secreted
Alternative names
Nka, Nkna, Tac2, Tac1, Protachykinin-1, PPT