TAC1
Function
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Post-translational modifications
Substance P
The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).
Sequence Similarities
Belongs to the tachykinin family.
Cellular localization
- Secreted
Alternative names
NKA, NKNA, TAC2, Protachykinin-1, PPT, Neurokinin A