TAC1

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Substance P

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).

Belongs to the tachykinin family.

• Secreted

NKA, NKNA, TAC2, Protachykinin-1, PPT, Neurokinin A

• swissprot:P20366

Proteins

15003Da