TACSTD2

May function as a growth factor receptor.

Corneal dystrophy, gelatinous drop-like

GDLD

A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.

None

The disease is caused by variants affecting the gene represented in this entry.

The N-terminus is blocked.

Belongs to the EPCAM family.

Placenta, pancreatic carcinoma cell lines.

• Membrane
• Single-pass type I membrane protein

GA733-1, M1S1, TROP2, TACSTD2, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1

• entrezGene:4070
• omim:137290
• swissprot:P09758

Proteins

Immuno-oncology

35709Da