TAF15
Function
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
Involvement in disease
A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.
Post-translational modifications
Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.
ADP-ribosylated during genotoxic stress.
Sequence Similarities
Belongs to the RRM TET family.
Tissue Specificity
Ubiquitous. Observed in all fetal and adult tissues.
Cellular localization
- Nucleus
- Cytoplasm
- Shuttles from the nucleus to the cytoplasm.
Alternative names
RBP56, TAF2N, TAF15, TATA-binding protein-associated factor 2N, 68 kDa TATA-binding protein-associated factor, RNA-binding protein 56, TAF(II)68, TAFII68