TAF4B
Function
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Involvement in disease
Spermatogenic failure 13
SPGF13
A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
Sequence Similarities
Belongs to the TAF4 family.
Tissue Specificity
Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.
Cellular localization
- Nucleus
- Cytoplasm
- Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Alternative names
TAF2C2, TAFII105, TAF4B, Transcription initiation factor TFIID subunit 4B, Transcription initiation factor TFIID 105 kDa subunit, TAF(II)105, TAFII-105