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Function

Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Alternative names

CG18492, Tak1, Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1, dTAK1

Target type

Proteins

Primary research area

Epigenetics

Other research areas

  • Oncology

Molecular weight

75675Da

We found 2 products in 1 category

Primary Antibodies

Target

Application

Reactive species

Search our catalogue for 'Tak1' (2)

Products

ab239353

Anti-TAK1 antibody [EPR22903-57]

Recombinant
RabMAb