TAL1

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).

Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).

Leukemic stem cell.

• Nucleus

BHLHA17, SCL, TCL5, TAL1, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, Stem cell protein, T-cell leukemia/lymphoma protein 5, bHLHa17

• entrezGene:6886
• omim:187040
• swissprot:P17542

Proteins

Epigenetics

34271Da