TAOK2 phospho S181

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

Isoforms 1 and 2 are autophosphorylated.

C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.

Autophosphorylated. Phosphorylated by ATM.

Isoform 2

Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Ubiquitously expressed, with a higher level of expression in testis and brain.

• Cytoplasmic vesicle membrane
• Multi-pass membrane protein
• Cytoplasm
• Cytoskeleton
• Nucleus
• Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.
• Isoform 2
• Cell projection
• Dendrite
• In dendrites, colocalizes with PCDH8.

KIAA0881, MAP3K17, PSK, PSK1, UNQ2971/PRO7431, TAOK2, Serine/threonine-protein kinase TAO2, Kinase from chicken homolog C, Prostate-derived sterile 20-like kinase 1, Thousand and one amino acid protein kinase 2, hKFC-C, PSK-1, Prostate-derived STE20-like kinase 1

• entrezGene:9344
• omim:613199
• swissprot:Q9UL54

Proteins

Neuroscience

138251Da