TAS2R38
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Sequence Similarities
Belongs to the G-protein coupled receptor T2R family.
Tissue Specificity
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
PTC, TAS2R38, Taste receptor type 2 member 38, T2R38, PTC bitter taste receptor, Taste receptor type 2 member 61, T2R61