Taste receptor type 2 member 8
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Sequence Similarities
Belongs to the G-protein coupled receptor T2R family.
Tissue Specificity
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
Taste receptor type 2 member 8, T2R8, Taste receptor family B member 5, TRB5, TAS2R8