TAT
Function
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Involvement in disease
Tyrosinemia 2
TYRSN2
An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and intellectual disability.
None
The disease is caused by variants affecting the gene represented in this entry.
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
Sequence Similarities
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Alternative names
Tyrosine aminotransferase, TAT, L-tyrosine:2-oxoglutarate aminotransferase