TATA box-binding protein-associated factor RNA polymerase I subunit C
Function
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Cellular localization
- Nucleus
- Nucleolus
Alternative names
TATA box-binding protein-associated factor RNA polymerase I subunit C, RNA polymerase I-specific TBP-associated factor 110 kDa, TATA box-binding protein-associated factor 1C, Transcription initiation factor SL1/TIF-IB subunit C, TAFI110, TBP-associated factor 1C, TAF1C