TAX1BP3
Function
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Tissue Specificity
Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.
Cellular localization
- Cytoplasm
- Nucleus
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Recruited to the cell membrane by interaction with membrane proteins.
Alternative names
TIP1, TAX1BP3, Tax1-binding protein 3, Glutaminase-interacting protein 3, Tax interaction protein 1, Tax-interacting protein 1, TIP-1