TBC1D10C
Domain
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.
Function
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Tissue Specificity
Most abundant in spleen and peripheral blood leukocytes.
Alternative names
Carabin, TBC1 domain family member 10C, TBC1D10C