TBC1D2

Function

Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.

Tissue Specificity

Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level).

Cellular localization

• Cytoplasm
• Cytoplasmic vesicle
• Cell junction

Alternative names

PARIS1, PP8997, TBC1D2A, TBC1D2, TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1

Database links

swissprot:Q9BYX2 entrezGene:55357 entrezGene:609871 omim:609871