Tbx5
Developmental stage
First expressed at day 7.5, exclusively in the allantois. At day 8.5, expressed only in the sinous venosus of the developing heart. At day 9.5, expression observed in the forelimb bud, optic vesicle and sinous venosus. By day 12.5, expression is limited to the retina, the body wall and the mesenchyme of the lung, of the mandible and of that surrounding the trachea.
Domain
The T-Box domain binds to double-stranded DNA.
Function
DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter.
Post-translational modifications
Acetylation at Lys-339 by KAT2A and KAT2B promotes nuclear retention.
Cellular localization
- Nucleus
- Cytoplasm
- Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention.
Alternative names
T-box transcription factor TBX5, T-box protein 5, Tbx5