TCERG1

The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5).

The WW domains bind Pro-rich domains.

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Detected in brain neurons.

• Nucleus

CA150, TAF2S, TCERG1, Transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150

• entrezGene:10915
• omim:605409
• swissprot:O14776

Proteins

123901Da