TCF25
Domain
The C-terminal region mediates transcriptional repression.
Function
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development (PubMed:16574069). May play a role in cell death control (By similarity).
Sequence Similarities
Belongs to the TCF25 family.
Tissue Specificity
In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.
Cellular localization
- Nucleus
- Cytoplasm
- Cytosol
- Mainly nuclear.
Alternative names
KIAA1049, NULP1, FKSG26, TCF25, Ribosome quality control complex subunit TCF25, Nuclear localized protein 1, Transcription factor 25, TCF-25