TCF7L1
Domain
The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
Function
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Sequence Similarities
Belongs to the TCF/LEF family.
Tissue Specificity
Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
Cellular localization
- Nucleus
Alternative names
TCF3, TCF7L1, Transcription factor 7-like 1, HMG box transcription factor 3, TCF-3