Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Hypertryptophanemia
HYPTRP
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.
None
The disease is caused by variants affecting the gene represented in this entry.
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Belongs to the tryptophan 2,3-dioxygenase family.
TDO, TDO2, Tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase, TO, TRPO
Proteins
Immuno-oncology
47872Da
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ab76859