TDO2
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Involvement in disease
Hypertryptophanemia
HYPTRP
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.
None
The disease is caused by variants affecting the gene represented in this entry.
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Sequence Similarities
Belongs to the tryptophan 2,3-dioxygenase family.
Alternative names
TDO, TDO2, Tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase, TO, TRPO