TEAD4/TEF-1

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Tissue specificity

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Cellular localization

• Nucleus

Alternative names

• Transcriptional enhancer factor TEF-3
• TEA domain family member 4
• Transcription factor 13-like 1
• Transcription factor RTEF-1
• TEAD-4
• RTEF1
• TCF13L1
• TEF3
• TEAD4

Database links

• entrezGene:8463
• entrezGene:7005
• entrezGene:7004
• entrezGene:7003
• omim:189967
• omim:603170
• omim:601714
• omim:601729
• swissprot:Q15561
• swissprot:P28347
• swissprot:Q15562
• swissprot:Q99594

Target type

Proteins

Primary research area

Oncology

Molecular weight

48329Da