TECTB
Domain
Zona pellucida domain may enable to form filaments.
Function
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Post-translational modifications
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Extracellular side
- Secreted
- Extracellular space
- Extracellular matrix
- Found in the non-collagenous matrix of the tectorial membrane.
Alternative names
Beta-tectorin, TECTB