TENM1
Domain
EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
Function
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).
Teneurin C-terminal-associated peptide
Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).
Ten-1 intracellular domain
Induces gene transcription activation.
Post-translational modifications
Teneurin C-terminal-associated peptide
Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).
Sequence Similarities
Belongs to the tenascin family. Teneurin subfamily.
Tissue Specificity
Expressed in fetal brain.
Cellular localization
- Cell membrane
- Single-pass membrane protein
- Ten-1 intracellular domain
- Nucleus
- Nucleus speckle
- Nucleus matrix
- Cytoplasm
- Cytoskeleton
- Teneurin C-terminal-associated peptide
- Nucleus
- Cytoplasm
- Cell membrane
- Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity).
Alternative names
ODZ1, TNM1, TENM1, Teneurin-1, Ten-1, Protein Odd Oz/ten-m homolog 1, Tenascin-M1, Teneurin transmembrane protein 1, Ten-m1