TENT5C
Function
Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:28931820, PubMed:32009146, PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (PubMed:34048638). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820).
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
Sequence Similarities
Belongs to the TENT family.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Recruited into the centrosome through its interaction with PLK4.
Alternative names
FAM46C, TENT5C, Terminal nucleotidyltransferase 5C, Non-canonical poly(A) polymerase FAM46C