TEP1
Function
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
- Chromosome
- Telomere
Alternative names
TLP1, TP1, TEP1, Telomerase protein component 1, Telomerase-associated protein 1, p240, p80 telomerase homolog, Telomerase protein 1