TESC
Developmental stage
Strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation, but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid differentiation (at protein level).
Domain
Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Sequence Similarities
Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Tissue Specificity
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Cellular localization
- Nucleus
- Cytoplasm
- Membrane
- Lipid-anchor
- Cell membrane
- Cell projection
- Lamellipodium
- Cell projection
- Ruffle membrane
- Colocalizes with SLC9A1 at the plasma membrane.
Alternative names
CHP3, TESC, Calcineurin B homologous protein 3, Tescalcin, TSC