TEX101
Function
Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).
Post-translational modifications
N-glycosylated; by high mannose and/or biantennary complex and/or certain types of hybrid oligosaccharides; possesses different oligosaccharides chains according to its subcellular localization in the testis.
Sheds from membrane raft by ACE and released from the cell surface of epididymal sperm while it passes through the caput epididymis leading to disappearance of TEX101 on spermatozoa; is essential to produce fertile spermatozoa.
Tissue Specificity
Detected in testis and spermatogonia. Not detected in spermatocytes. Detected in blood leukocytes.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Membrane raft
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Secreted
- Cytoplasmic vesicle
- Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa.
Alternative names
SGRG, UNQ867/PRO1884, TEX101, Testis-expressed protein 101, Cell surface receptor NYD-SP8, Scleroderma-associated autoantigen, Spermatogenesis-related gene protein