Tfap2c

The PPxY motif mediates interaction with WWOX.

Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:38243114, PubMed:8660922). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:38243114, PubMed:8660922). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (PubMed:38243114). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (PubMed:38243114). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (PubMed:38243114). Binds to both closed and open chromatin with other transcription factors (PubMed:38243114).

Sumoylated on Lys-10; which inhibits transcriptional activity.

Belongs to the AP-2 family.

Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.

• Nucleus

Tcfap2c, Transcription factor AP-2 gamma, AP2-gamma, AP-2.2, Activating enhancer-binding protein 2 gamma

• swissprot:Q61312

Proteins

49137Da