Tff3

Function

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity).

Tissue Specificity

Expressed in goblet cells of the intestines, and colon, in paraventricular hypothalamus and supraoptic nuclei. Weakly expressed in gastric epithelial cells (at protein level). Expressed by goblet cells of small and large intestinal epithelia, kidney and stomach. Expressed in the paraventricular hypothalamus, arcuate nucleus and amygdala of the brain. Weakly expressed in gastric epithelial cells.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Cytoplasm

Alternative names

Itf, Tff3, Trefoil factor 3, Intestinal trefoil factor, Polypeptide P1.B, rITF, rP1.B

Database links

swissprot:Q03191 entrezGene:25563

Other research areas

• Oncology