TFF3

Function

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Tissue Specificity

Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level).

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Cytoplasm

Alternative names

ITF, TFI, TFF3, Trefoil factor 3, Intestinal trefoil factor, Polypeptide P1.B, hITF, hP1.B

Database links

swissprot:Q07654 entrezGene:7033 omim:600633

Other research areas

• Oncology