This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
O-glycosylated.
Mostly in endothelial cells.
LACI, TFPI1, TFPI, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, Lipoprotein-associated coagulation inhibitor, EPI
Proteins
Cardiovascular
35015Da
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