Tfr2
Developmental stage
First expressed between embryo days 8 and 11. In the liver, expression increases during development from embryo day 13 to adulthood while, in the spleen, levels remain constant throughout development.
Function
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Sequence Similarities
Belongs to the peptidase M28 family. M28B subfamily.
Tissue Specificity
Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Isoform 3
- Cytoplasm
Alternative names
Trfr2, Tfr2, Transferrin receptor protein 2, TfR2