TGFBI

Expressed in the embryo at 12 dpc (PubMed:8024701).

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.

The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.

Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701).

• Secreted
• Secreted
• Extracellular space
• Extracellular matrix
• May be associated both with microfibrils and with the cell surface.

Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Tgfbi

• swissprot:P82198

Proteins

Oncology

74597Da