Tgfbi
Developmental stage
Expressed in the embryo at 12 dpc (PubMed:8024701).
Function
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).
Post-translational modifications
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.
The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.
Tissue Specificity
Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus (PubMed:8024701).
Cellular localization
- Secreted
- Secreted
- Extracellular space
- Extracellular matrix
- May be associated both with microfibrils and with the cell surface.
Alternative names
Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Tgfbi