TH

Developmental stage

Expressed in the retinal inner nuclear layer and outer nuclear layer at postnatal day 8 (P8) (PubMed:30936473). Expressed in retinal dopaminergic amacrine cells in the retina at P8 and P15 (PubMed:30936473).

Function

Plays an important role in the physiology of adrenergic neurons (Probable). Positively regulates the regression of retinal hyaloid vessels during postnatal development (PubMed:30936473).

Pathway

Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Tissue specificity

Expressed in the adrenal gland (PubMed:1674869). Expressed in the retina (PubMed:30936473).

Cellular localization

• Cytoplasm
• Perinuclear region

Alternative names

• Tyrosine 3-monooxygenase
• Tyrosine 3-hydroxylase
• TH
• Th

Database links

• entrezGene:21823
• swissprot:P24529

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

55993Da